Drug discovery is the process by which a new drug candidate or lead compound is identified and validated for treating specific disease. Drug discovery is long term complex process implying large number of steps right from selecting active ingredient to clinical trials and getting appropriate approvals. The first stage in drug discovery is to understand disease mechanism from cellular as well genetic level, in order to identify potential drug targets. Once disease mechanism is validated, the next step is development of cell assays to measure activity of similar compounds that can affect activity of target disease cell. Many biotech and pharmaceutical companies have small molecule compound libraries which can be used for screening of potential compounds. In-vivo and in-vitro studies or trials are used to understand potential course of action of compound and to ascertain toxicology or possible side effects on human body. Drug discovery involves long term interaction between research institutes, academics, regulatory bodies & industry and marketing agencies for commercializing drug for public health.
Drug discovery is a multidiscipline approach integrating disciplines including genomics, bioinformatics, cell biology and structural biology to name a few. Advancements in genome sequencing have revolutionized drug discovery press. Genome sequencing is analyzing complete DNA structure of organism to understand genetic makeup of organism for accessing underlying cause of various diseases. Genomic technologies such as statistical genetics, gene sequencing and gene sequencing analysis are used in experimental and clinical trials for drug discovery. These genome based technologies aid in drug development by identifying new target sites, providing exclusive information by computer aided design of lead compounds and target validation through disease and predictive toxicology models.
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Increasing elderly population with high risk of developing chronic diseases, expiry of leading patents and advancements in the field of biotechnology and molecular biology will drive growth of the global drug discovery technologies market. In addition, increasing resistance of pathogens to traditional drugs will increase demand for advanced therapeutics leading to rapid growth of the market. However, presence of strict approval guidelines, high cost and long duration of drug discovery process will slow down growth of the global market.
Major players operating in the global market include Bayer Healthcare AG, Albany Molecular Research Inc., AstraZeneca plc, Luminex Corporation, Agilent Technologies, Bio-Rad Laboratories, Albany Molecular Research, Thermo Fisher Scientific and Charles River Laboratories International, Inc. Strategic collaborations and partnership are key strategies adopted by market players for expanding their geographical business boundaries and product portfolio. For instance, in February 2017, Albany Molecular Research Inc. has formed strategic alliance with Bruker Daltonics and HighRes Biosolutions to expand their product portfolio by developing new applications for drug discovery through high mass spectrometry. This strategic alliance will accelerate growth of Albany Molecular Research Inc. thereby strengthening global position of the company.
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The continuous advancements in technologies such as 3D printing, next generation sequencing, gene therapy, stem cell therapies, and microbiomics will provide ample growth opportunities for market players. Advancements in Bioinformatics are expected to shape the pharmaceutical industry and will enhance drug development technologies for giving high value to healthcare providers as well as patients at low cost. Moreover advancement in technologies and instrument will further accelerate growth of the market players. For instance, Thermo Fisher Scientific in June 2016, had launched ultra-high-performance liquid chromatography (UHPLC) system provides high speed, reliable and sensitive biocompatible analysis for easy identification of pharmaceutical ingredients for drug development and designing.
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